1682 - LaSalle claims Mississippi Valley for France
1763 - Treaty of Paris; Spanish obtain territory from France
1769 - Lewis Blanchette settles "Les Petites Cotes" meaning "little hills"
1769-1799 Daniel Boone builds log cabin in Saint Charles County
1791 - Les Petites Cotes" becomes "San Carlos" to honor Charles IV of Spain with the name of his patron saint, Bishop Carlos Borromeo
1791 - Borromeo Church is established
1803 - The Louisiana Purchase
1804 - Land transferred from France to US; Spanish name of San Carlos is anglicized to Saint Charles
1804 - Lewis and Clark expedition heads west from Saint Charles
1805 - St. Louis is capitol of Louisiana Territory
1809 - St. Charles is incorporated as a city
1812 - Saint Charles County is organized as one of the five original Missouri counties
1815 - Treaty of Portage des Sioux
1818 - Academy of the Sacred Heart established by Philippine Duchesne
1820 - Daniel Boone dies and is buried in Defiance
1821 - Missouri becomes the 24th state
1821-1826 - Saint Charles is Missouri state capitol
1827 - Lindenwood College opens
1830s - German immigration increases due, in part, to a book observing life in the area
1849 - City of Saint Charles is incorporated
1850 - Railroad construction begins
1871 - First railroad bridge to span the Missouri River opens
1874 - First railroad car rolls off the line at the St. Charles Car Company
1876 - Cyclone destroys city
1879 & 1881 - Spans of the Railroad Bridge collapse
1885 - St. Joseph Hospital opens
1892 - Katy Railroad Depot opens
1894 - Three railroads completed
1899 - St. Charles Car Company merges to form American Car & Foundry
1901 - County Court House is started
1904 - First highway bridge to Saint Charles opens in time for the Worlds Fair in St. Louis; Streetcar service becomes available
1916 - Tornado destroys Borromeo Church
1921-1924 - Construction on modern highway system begins
1931 - Daniel Boone Bridge opens, spans Missouri River
1932 - Streetcar service ends
1935 - Spans of railroad bridge collapse
1945 - American Car & Foundry switches production to build light tanks for the war effort
1958 - Katy Depot closes
1959 - American Car & Foundry ceases production
1969 - First State Capitol declared a State Historic Site
1969 - Katy Depot is relocated to Frontier Park
1992 - Discovery Bridge opens
1993 - Great Flood
1994 - Clark Bridge links Saint Charles & Illinois
1997 - Highway 115 Bridge is demolished
2000 - Census marks population at 283,000
2004 - Part of the railroad foundry is renovated as a The Foundry Art Centre
2009 - St. Charles will celebrate 200 years as an incorporated city